For Patients
Apollo Bredesen Program
A proven path to protect and restore cognitive health. Atlanta's certified Bredesen Protocol program for Alzheimer's prevention and cognitive decline reversal, for anyone watching a loved one change or confronting their own risk.
When Memory Starts to Slip
You Are Not Powerless
A parent repeating the same story. A spouse forgetting names they have known for decades. Losing the thread of a conversation mid-sentence. The fear sits underneath every small moment. Dr. Dale Bredesen's protocol was the first program clinically shown to halt and, in many cases, reverse cognitive decline by addressing its root causes. Progressive Medical Center delivers that protocol in Atlanta, with a dedicated program team and the full range of integrative therapies under one roof.
No referral needed. A care coordinator will help determine whether the prevention or treatment track is right for you.
Why Acting Early Matters
Cognitive Decline Can Start Earlier Than You Think
Alzheimer's is commonly thought of as a disease of the very old. That is not the full picture. The biological changes that lead to cognitive decline can begin decades before the first noticeable symptoms, sometimes as early as a person's 40s or 50s. The earlier those changes are identified, the more effective the protocol is at protecting what is still intact.
Contributing factors are broader than many patients expect. Environmental toxin exposure. Post-COVID cognitive effects. Genetic markers, including the APOE gene. Chronic inflammation. Hormonal imbalance. Blood sugar dysregulation. Sleep disruption. Nutrient deficiency. Gut dysbiosis. The Bredesen Protocol organizes these into more than 36 contributing factors and evaluates each one systematically.
This is not only a program for people who already have a diagnosis. Patients with a family history of Alzheimer's, patients who carry one or two copies of the APOE e4 variant, and patients noticing their own subtle early changes are the ideal candidates for the prevention track. Acting on risk before symptoms develop is the single strongest lever in brain health.
Genetic risk is not destiny. It is a reason to act earlier.
How the Protocol Works
The Bredesen Protocol at Progressive Medical Center
Dr. Dale Bredesen, a neurologist and researcher, identified cognitive decline as a condition driven by more than 36 interacting contributors rather than a single cause. The Bredesen Protocol was the first program to address all of those contributors simultaneously. Progressive Medical Center offers the full protocol through certified practitioners, delivered alongside the advanced diagnostics and integrative therapies already in place at the clinic.
PreCODE Report: The Prevention Track
For patients who are asymptomatic but at elevated risk. Family history of Alzheimer's. APOE e4 carriers. Patients in their 40s and 50s who want to protect cognitive function while the window is widest. The PreCODE Report maps your modifiable risk factors and builds a personalized prevention plan backed by your own biomarker data.
ReCODE Report: The Treatment Track
For patients already experiencing memory loss, brain fog, or diagnosed cognitive decline. The ReCODE Report identifies the specific biological pathways driving your decline and translates them into a targeted treatment plan. PMC delivers the ReCODE 2.0 version, Dr. Bredesen's current protocol.
Conventional Alzheimer's care relies on single-drug symptom management. The Bredesen Protocol treats cognitive decline as a systemic problem with systemic solutions. Both tracks are built around your own biology.
What to Expect
Your Program Journey
The program is a sustained partnership, not a single appointment. Here is what the experience looks like.
Initial Consultation
Your first visit is a comprehensive intake with a member of the Apollo/Bredesen program team. Medical history, family history, cognitive concerns, lifestyle patterns, and any prior workups are reviewed together. The consultation determines whether the PreCODE prevention track or the ReCODE treatment track is the right starting point for you. Initial consultation is $250.
Advanced Diagnostics
Bredesen's framework identifies more than 36 contributors to cognitive decline. Your diagnostic workup is built to evaluate each one as it applies to you. This typically includes APOE genetic testing, cognitive assessment, inflammatory and metabolic biomarkers, hormone panels, nutrient status, toxic burden screening, and imaging where indicated. The goal is specificity: which contributors are active in your biology right now.
Your Personalized Report
Your findings are compiled into either a PreCODE Report (prevention track) or a ReCODE Report (treatment track). The report is not a list of generic recommendations. It is a detailed map of the factors driving your cognitive risk or decline, with a custom treatment plan built on what your diagnostics actually found.
Treatment Plan Implementation
Your plan draws on the Bredesen framework and the full range of PMC integrative therapies. Supporting modalities are chosen to match what your report surfaced. Commonly integrated therapies include:
- Biofeedback and brain mapping for cognitive assessment and training
- Hyperbaric oxygen therapy for neuroinflammation and neurogenesis support
- IV therapy with neuroprotective protocols including glutathione and NAD+
- Peptide therapy for neuroprotection and cognitive support
- Detoxification for toxic burden identified in diagnostics
Nutrition, supplementation, sleep, exercise, and stress protocols are layered on top of these in-clinic therapies.
Ongoing Monitoring
Cognitive health is measured over months and years, not a single appointment. Follow-up assessments, biomarker rechecks, and protocol adjustments are built into the program. Dr. Bredesen's published research, and the outcomes PMC has tracked in the program's own patients, show that measurable improvement is possible when root causes are identified and addressed early enough.
Ready to take the first step? Call (770) 676-6000 to schedule your initial consultation.
Your Care Team
Meet Your Program Team
Two practitioners lead the program. Both carry professional expertise and personal connection to Alzheimer's, and both work within PMC's broader multidisciplinary team.
Gena Mastrogianakis, MD
Program Director
Known to her patients as Dr. Mastro, Dr. Mastrogianakis is a board-certified family medicine physician trained at Emory University. Between medical school and residency, she spent three years at Emory's Winship Cancer Institute as a Senior Research Project Manager on an NIH-funded study housed within the department of Neurosurgery. That work resulted in publications in Nature and Cell, two of the world's most respected scientific journals. She spent an additional two years in Emory's Neurosurgery department creating and managing a Pituitary Tumor Database. That foundation in neuroscience connects directly to her current role leading the Apollo/Bredesen program.
- Board Certified Family Medicine
- Emory University Residency
- NIH Research at Emory Winship Cancer Institute
- Published in Nature and Cell
- Institute of Functional Medicine affiliation
Mike Stamps
Brain Health Protocol Director
Before healthcare, Mike built a career in brand management and sales leadership at Procter & Gamble, followed by leadership roles in multiple technology ventures. His path to this work is personal. Alzheimer's claimed the lives of both his mother and his grandmother. That family experience drove him to study the causes and treatments of neurodegenerative disease, and his research led him to Dr. Dale Bredesen's work at Apollo Health. In 2023, Mike joined Progressive Medical Center as Program Director for the Brain Health Protocol. He and Progressive now collaborate with Apollo Health to deliver the Bredesen Protocol to patients across metro Atlanta and the Southeast.
- Brain Health Protocol Director
- Apollo Health / Bredesen Protocol Trained
- Former P&G Brand Management and Sales Leadership
- Joined PMC in 2023
The program team works alongside PMC's wider clinical staff, including the diagnostic department, IV department, and naturopathic team, so every piece of your plan is delivered by the right specialist.
Common Questions
Frequently Asked Questions
What is the Bredesen Protocol?
The Bredesen Protocol is a multi-factor approach to cognitive decline developed by neurologist Dr. Dale Bredesen. It identifies more than 36 contributing factors, including inflammation, infections, toxic burden, nutrient status, hormones, and vascular health, and addresses them simultaneously rather than treating symptoms alone. Dr. Bredesen's published research remains the clearest evidence base for cognitive decline as a reversible systemic condition when caught early enough.
Who is the Apollo/Bredesen Program for?
Two audiences. First, people already experiencing memory loss, brain fog, or diagnosed cognitive decline, who enroll in the ReCODE treatment track. Second, people with a family history of Alzheimer's, known genetic risk such as APOE e4 carriers, or early subtle changes, who enroll in the PreCODE prevention track. Both tracks begin with the same initial consultation.
How much does the program cost?
The initial consultation is $250. Full program pricing depends on which diagnostics your practitioner orders and which therapies your treatment plan includes. A care coordinator will walk through the expected range during your intake call, and financing is available. Learn more on our Insurance & Financing page.
Is the Bredesen Protocol covered by insurance?
Progressive Medical Center is out of network for all insurance providers, which allows the program to operate on root-cause evaluation rather than coverage-driven protocols. Some diagnostic lab work may qualify for out-of-network reimbursement. Superbills are provided on request. Cherry Financing and CareCredit are available for qualifying patients. Insurance & Financing details.
Can Alzheimer's be reversed?
Dr. Bredesen's published research demonstrates that cognitive decline can be halted and, in many cases, reversed when the underlying root causes are identified and addressed early enough. Results vary by individual, by stage of decline, and by adherence to the protocol. Andie G., a program participant who carried the APOE 4/4 gene, described her own outcome as "energy, focus, and cognitive test scores improved dramatically" within months. Early intervention produces the strongest results.
How long does the program take?
The diagnostic phase typically runs several weeks, depending on how many panels are ordered and how quickly results return. Treatment is ongoing and personalized. Many patients see measurable improvement within the first several months, with continued monitoring and protocol refinement over the longer term. The program is designed as a sustained partnership, not a single appointment.
What makes PMC's program different from other Bredesen providers?
Most Bredesen practitioners refer patients elsewhere for the supporting treatments the protocol calls for. Progressive Medical Center delivers the protocol alongside hyperbaric oxygen, IV therapy, brain mapping, peptide therapy, and detoxification under one roof. Everything is coordinated by one team, with 27 years of integrative medicine experience behind the broader clinic.
How do I get started?
Call (770) 676-6000 to speak with a care coordinator. The coordinator will help determine whether the PreCODE prevention track or the ReCODE treatment track is the right fit for your situation, answer questions from family members, and schedule your initial consultation. No referral needed.
Take the First Step Toward Protecting Your Cognitive Health
Whether you are facing a diagnosis or acting on a family history, the program team is here to help you understand your options. A care coordinator will answer your questions and help determine whether the prevention or treatment track is the right fit.